Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25824934 | 0.83 | NPC1 (0.46) | KMT2AALDH1A1HPGDMEN1SMN1; SMN2 | |
| SCHEMBL22698935 | 0.79 | CHRNB2 (0.56) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5987689 | 0.79 | CHRNB2 (0.56) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL22698966 | 0.79 | KMT2A (0.51) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL24322684 | 0.78 | KMT2A (0.54) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL17003840 | 0.78 | KMT2A (0.50) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL13188546 | 0.78 | KMT2A (0.54) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL16373570 | 0.76 | KMT2A (0.49) | KMT2ATP53KDM4EALDH1A1HPGD | |
| SCHEMBL24491469 | 0.76 | CHRNB2 (0.41) | KMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL24023958 | 0.75 | CHRNB2 (0.36) | SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313397-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME (US) | 2020-11-25 | — | — | EP | disclosed |