SCHEMBL22699591

SCHEMBL22699591

O=C(O)c1c(-c2ccc(Cl)cc2)csc1NC(O)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ANO1 Q5XXA6 19/20 0.61
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
ANO2 Q9NQ90 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22699633 0.91 KMT2A (0.55) ANO1MEN1KMT2A
SCHEMBL22699625 0.84 ANO1 (0.50) ANO1MEN1KMT2AANO2
SCHEMBL22699595 0.84 MEN1 (0.51) ANO1MEN1KMT2A
SCHEMBL3629322 0.80 ANO1 (0.64) ANO1MEN1KMT2AANO2
SCHEMBL1954143 0.80 ANO1 (0.64) ANO1MEN1KMT2AANO2
SCHEMBL12271278 0.80 ANO1 (0.80) ANO1MEN1KMT2AANO2
SCHEMBL22965397 0.79 MEN1 (0.41) ANO1MEN1KMT2A
SCHEMBL3629193 0.78 ANO1 (0.61) ANO1MEN1KMT2AANO2
SCHEMBL1907137 0.78 ANO1 (0.65) ANO1MEN1KMT2A
SCHEMBL21259091 0.77 ANO1 (0.64) ANO1ANO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11840527-B2 Non-fused thiophene derivatives and their uses ENYO PHARMA (FR) 2023-12-12 US disclosed
US-20200369655-A1 NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES ENYO PHARMA (FR) 2020-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369655-A1 NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES FTH1, SLC40A1, FECH ANO1 4308/4885MEN1 3578/4885KMT2A 3273/4885
US-11840527-B2 Non-fused thiophene derivatives and their uses FTH1, SLC40A1, FECH ANO1 4308/4885MEN1 3578/4885KMT2A 3273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.