Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.80 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.66 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462302 | 0.79 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL8963903 | 0.78 | HRH3 (0.73) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL4680197 | 0.77 | HRH3 (0.51) | HRH3HRH4HTR3AHRH2LMNA | |
| SCHEMBL4680200 | 0.77 | HRH3 (0.56) | HRH3HRH4 | |
| SCHEMBL20215726 | 0.76 | HRH3 (0.54) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL5107846 | 0.74 | — | — | |
| SCHEMBL8963886 | 0.73 | HRH3 (0.75) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL8964986 | 0.73 | HRH3 (0.79) | HRH3HRH4HRH2HRH1 | |
| SCHEMBL4681311 | 0.72 | CXCR4 (0.57) | HRH3HRH4HTR3A | |
| SCHEMBL4681304 | 0.72 | HRH4 (0.50) | HRH3HRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |