Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681304 | 0.83 | HRH4 (0.50) | HRH3HRH4HTR3A | |
| SCHEMBL22701433 | 0.77 | HRH3 (0.80) | HRH3HRH4HTR3AHRH2LMNA | |
| SCHEMBL8963903 | 0.71 | HRH3 (0.73) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL4680200 | 0.70 | HRH3 (0.56) | HRH3HRH4 | |
| SCHEMBL21594260 | 0.68 | HRH3 (0.52) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL8963886 | 0.67 | HRH3 (0.75) | HRH3HRH4HRH2LMNAMIF | |
| SCHEMBL8964986 | 0.67 | HRH3 (0.79) | HRH3HRH4HRH2HRH1 | |
| SCHEMBL29462302 | 0.66 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL4681311 | 0.66 | CXCR4 (0.57) | HRH3HRH4HTR3A | |
| SCHEMBL890317 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B8 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1416933-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgem, Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009847-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM, INC. (US) | 2003-02-06 | — | — | WO | disclosed |