Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513683 | 0.82 | EPHX1 (0.45) | KMT2AKDM4ESMN1; SMN2ANPEPEPHX1 | |
| SCHEMBL7513675 | 0.82 | EPHX1 (0.45) | KMT2AKDM4ESMN1; SMN2ANPEPEPHX1 | |
| SCHEMBL3037199 | 0.82 | ALDH1A1 (0.58) | KMT2AKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11444360 | 0.82 | ALDH1A1 (0.58) | KMT2AKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL21224118 | 0.81 | APP (0.43) | CCNCCDK8KMT2AKDM4EANPEP | |
| SCHEMBL15091449 | 0.77 | CA12 (0.53) | CCNCCDK8KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL15091450 | 0.77 | CA12 (0.53) | CCNCCDK8KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL22701952 | 0.76 | SMN1; SMN2 (0.43) | KMT2AKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL22701982 | 0.76 | MAPT (0.41) | KMT2AKDM4ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19333554 | 0.76 | KMT2A (0.53) | CCNCCDK8KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411361-B1 | NRF2 ACTIVATING COMPOUNDS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2020-11-25 | — | — | EP | disclosed |