Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22701952 | 0.83 | SMN1; SMN2 (0.43) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3037199 | 0.82 | ALDH1A1 (0.58) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11444360 | 0.82 | ALDH1A1 (0.58) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22701975 | 0.82 | MAPT (0.45) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22701983 | 0.79 | KMT2A (0.55) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22701981 | 0.78 | ALDH1A1 (0.47) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22701935 | 0.76 | CCNC (0.45) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5259514 | 0.73 | CA12 (0.70) | MAPTALDH1A1LMNACA12CA1 | |
| SCHEMBL403043 | 0.73 | CA12 (0.70) | MAPTALDH1A1LMNACA12CA1 | |
| SCHEMBL403042 | 0.73 | CA12 (0.70) | MAPTALDH1A1LMNACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411361-B1 | NRF2 ACTIVATING COMPOUNDS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2020-11-25 | — | — | EP | disclosed |