Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377889 | 0.80 | NOTUM (0.52) | TRPV1APPAMY1AALDH1A1TDP1 | |
| SCHEMBL18367585 | 0.77 | TRPV1 (0.49) | TRPV1APPAMY1AALDH1A1TDP1 | |
| SCHEMBL19732301 | 0.76 | TRPV1 (0.61) | TRPV1APPAMY1AALDH1A1RXRA | |
| SCHEMBL28875210 | 0.74 | BCHE (0.60) | TRPV1APPAMY1ALMNACA1 | |
| SCHEMBL21849198 | 0.71 | TRPV1 (0.43) | TRPV1APPAMY1AHSD11B1RXRA | |
| SCHEMBL23557635 | 0.70 | MIF (0.54) | TRPV1APPCA1CA2CA5A | |
| SCHEMBL21849514 | 0.67 | TRPV1 (0.43) | TRPV1APPAMY1AHSD11B1RXRA | |
| SCHEMBL28329509 | 0.66 | NOTUM (0.41) | TRPV1RXRAGRIN1GRIN2BCA1 | |
| SCHEMBL4324877 | 0.66 | ALDH1A1 (0.53) | TRPV1ALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL27048495 | 0.65 | AADAT (0.43) | TRPV1APPALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319955-B1 | 6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS | GILEAD SCIENCES INC (US) | 2020-11-25 | — | — | EP | disclosed |