Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18982613 | 0.89 | ALDH1A1 (0.41) | CNR2MEN1KMT2AMAPTNPSR1 | |
| SCHEMBL18982556 | 0.89 | CNR2 (0.44) | CNR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17318022 | 0.89 | MAPT (0.42) | CNR2MEN1KMT2AMAPTNPSR1 | |
| SCHEMBL16796000 | 0.89 | ABCB11 (0.50) | CNR2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL16807989 | 0.89 | CNR2 (0.36) | CNR2MEN1KMT2AABCB11CYP1A2 | |
| SCHEMBL18982849 | 0.82 | MAPT (0.40) | CNR2MAPTPPARASMN1; SMN2ALDH1A1 | |
| SCHEMBL18982146 | 0.82 | CYP1A2 (0.42) | KMT2ANPSR1CYP1A2CYP3A4GAA | |
| SCHEMBL18982653 | 0.81 | CYP4F2 (0.43) | CNR2KMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL19006603 | 0.80 | MAPT (0.41) | CNR2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL19006415 | 0.80 | CA12 (0.44) | MAPTNPSR1CYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3079700-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2020-11-25 | — | — | EP | disclosed |