Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22705269 | 0.81 | TTR (0.31) | TTRALBGAA | |
| SCHEMBL22025951 | 0.77 | TTR (0.33) | TTRALB | |
| SCHEMBL22705202 | 0.77 | — | — | |
| SCHEMBL2154261 | 0.73 | TTR (0.39) | TTRALBALDH1A1 | |
| SCHEMBL25138979 | 0.73 | KDM4E (0.34) | TTRALBKDM4EALDH1A1 | |
| SCHEMBL22012206 | 0.71 | GAA (0.46) | KDM4EALDH1A1LMNAGAA | |
| SCHEMBL22705144 | 0.71 | ABCC9 (0.37) | — | |
| SCHEMBL22899690 | 0.71 | TTR (0.38) | TTRALBALDH1A1 | |
| SCHEMBL19505731 | 0.71 | TTR (0.38) | TTRALBALDH1A1LMNA | |
| SCHEMBL2155740 | 0.71 | TTR (0.38) | TTRALBKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445756-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-07-06 | — | — | EP | disclosed |
| EP-3445757-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RES INC (US) | 2020-11-25 | — | — | EP | disclosed |