Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.47 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20469871 | 0.83 | RXRA (0.44) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL9092770 | 0.80 | RXRA (0.53) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL20456630 | 0.78 | RXRA (0.49) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL31565004 | 0.78 | RXRA (0.49) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL15465888 | 0.78 | RXRA (0.50) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL3365242 | 0.74 | RXRA (0.50) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL12841491 | 0.71 | SIGMAR1 (0.39) | ALDH1A1SIGMAR1MEN1LMNAKMT2A | |
| SCHEMBL16559080 | 0.70 | RXRA (0.47) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL6720742 | 0.69 | BCL2L1 (0.44) | RXRARXRBRXRGBCL2L1BAD | |
| SCHEMBL11775628 | 0.69 | RXRA (0.49) | RXRARXRBRXRGBCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445757-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RES INC (US) | 2020-11-25 | — | — | EP | disclosed |