Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.43 |
| ▸ | FABP1 | P07148 | 2/20 | 0.41 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705737 | 0.86 | NR1H4 (0.47) | NR1H4FABP1HSD17B13 | |
| SCHEMBL24565512 | 0.84 | NR1H4 (0.46) | NR1H4FABP1HSD17B13 | |
| SCHEMBL19689533 | 0.75 | NR1H4 (0.44) | NR1H4FABP1HSD17B13 | |
| SCHEMBL28320904 | 0.74 | NR1H4 (0.46) | NR1H4FABP1HSD17B13 | |
| SCHEMBL19689512 | 0.74 | NR1H4 (0.46) | NR1H4FABP1HSD17B13 | |
| SCHEMBL28870286 | 0.72 | NR1H4 (0.43) | NR1H4FABP1HSD17B13 | |
| SCHEMBL29662860 | 0.71 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL19689496 | 0.71 | NR1H4 (0.57) | NR1H4FABP1HSD17B13 | |
| SCHEMBL20859034 | 0.69 | NR1H4 (0.55) | NR1H4FABP1HSD17B13 | |
| SCHEMBL20094441 | 0.69 | NR1H4 (0.60) | NR1H4FABP1HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200369632-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369632-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | NR1H4 1/4885FABP1 15/4885HSD17B13 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.