Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14361896 | 0.90 | PHGDH (0.67) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14358433 | 0.90 | PHGDH (0.67) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10720943 | 0.83 | PHGDH (0.81) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1662915 | 0.82 | PHGDH (0.65) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4906405 | 0.81 | PHGDH (0.63) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3671231 | 0.80 | APP (0.56) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3671228 | 0.80 | APP (0.56) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4107083 | 0.78 | PHGDH (0.49) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4107086 | 0.78 | PHGDH (0.49) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1017455 | 0.78 | PHGDH (0.69) | PHGDHHPGDSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | NEW YORK UNIVERSITY (US) | 2022-07-26 | — | — | US | disclosed |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | NEW YORK UNIVERSITY | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | CAMKK2, CAMKK1, CAMK1 | PHGDH 1434/4885HPGD 1168/4885SMN1; SMN2 1047/4885 |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | CAMKK2, CAMKK1, CAMK1 | PHGDH 1434/4885HPGD 1168/4885SMN1; SMN2 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.