SCHEMBL22710285

SCHEMBL22710285

NC(=O)c1cc(Cc2ccccc2F)n[nH]1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.47
AR P10275 1/20 0.43
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
PARP15 Q460N3 2/20 0.40
PARP10 Q53GL7 2/20 0.40
MAOB P27338 1/20 0.40
PARP14 Q460N5 1/20 0.40
MPO P05164 1/20 0.39
DAO P14920 1/20 0.38
NR3C2 P08235 1/20 0.37
F2 P00734 1/20 0.37
SCN9A Q15858 1/20 0.36
ADORA2A P29274 1/20 0.36
MAPK8 P45983 1/20 0.36
PTPN1 P18031 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4676819 0.79 HCAR3 (0.44) HCAR3ARALDH1A1KDM4EMPO
SCHEMBL15965383 0.79 HCAR2 (0.46) HCAR3DAO
SCHEMBL2928229 0.77 MPO (0.47) HCAR3ARALDH1A1KDM4EMPO
SCHEMBL22710184 0.76 HCAR2 (0.51) PARP10MAOBMPODAONR3C2
SCHEMBL14719562 0.75 AR (0.54) HCAR3ARALDH1A1KDM4EMPO
SCHEMBL15964815 0.74 HCAR2 (0.49) HCAR3ARALDH1A1KDM4EPARP15
SCHEMBL4679194 0.73 HCAR3 (0.39) HCAR3ARALDH1A1KDM4EMPO
SCHEMBL15964734 0.72 HCAR3 (0.47) HCAR3DAONR3C2
SCHEMBL29444427 0.72 PLA2G10 (0.54) SCN9A
SCHEMBL1568696 0.71 PARP10 (0.49) ALDH1A1PARP15PARP10MAOBPARP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3342771-B1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-11-25 EP disclosed