Sugi Predict

Sugi Predict / Compounds / SCHEMBL22714770

SCHEMBL22714770

SCHEMBL22714770

COc1cc(-c2ncc(C)s2)cc2c(NCc3ccc(F)cn3)ncnc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLK4 Q9HAZ1 4/20 0.43
▸ USP2 O75604 3/20 0.43
▸ LMNA P02545 3/20 0.43
▸ CYP1A2 P05177 3/20 0.43
▸ CYP3A4 P08684 3/20 0.43
▸ CYP2D6 P10635 3/20 0.43
▸ CYP2C19 P33261 3/20 0.43
▸ TSHR P16473 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ EGFR P00533 2/20 0.41
▸ PDE5A O76074 10/20 0.39
▸ ALDH1A1 P00352 3/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ CD38 P28907 1/20 0.38
▸ ADORA2A P29274 1/20 0.37
▸ AURKA O14965 1/20 0.37
▸ GRK4 P32298 1/20 0.37
▸ GRK5 P34947 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29676375 1.00 CLK4 (0.43) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL29676393 0.89 PDE5A (0.47) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL28671205 0.89 PDE5A (0.47) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL29676562 0.88 CNR1 (0.43) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL22714691 0.88 CNR1 (0.43) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL22714768 0.86 P2RX3 (0.45) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL29481339 0.86 P2RX3 (0.45) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL22714775 0.85 EGFR (0.48) CLK4USP2LMNACYP1A2CYP3A4
SCHEMBL22715541 0.85 PDE5A (0.39) CLK4EGFRPDE5AALDH1A1KDM4E
SCHEMBL29676421 0.85 PDE5A (0.39) CLK4EGFRPDE5AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12466820-B2 Amino quinazoline derivatives as P2X3 inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2025-11-11 — — US claimed
CN-113891745-B As P2X3Aminoquinazoline derivatives of inhibitors 奇斯药制品公司 2024-05-07 — — CN claimed
US-20220227749-A1 AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS CHARLES RIVER LABORATORIES, INC. 2022-07-21 — — US claimed
CN-113891745-A As P2X3Aminoquinazoline derivatives as inhibitors 奇斯药制品公司 2022-01-04 — — CN claimed
WO-2020239952-A1 AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2020-12-03 — — WO claimed
US-20220227749-A1 AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS CHARLES RIVER LABORATORIES, INC. 2022-07-21 — — US disclosed
WO-2020239952-A1 AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2020-12-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220227749-A1 AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS P2RX3, P2RX5, P2RX1 CLK4 3322/4885USP2 3470/4885LMNA 3348/4885
US-12466820-B2 Amino quinazoline derivatives as P2X3 inhibitors P2RX3, P2RX5, P2RX1 CLK4 3322/4885USP2 3470/4885LMNA 3348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.