Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495797 | 0.79 | NUDT1 (0.48) | NOTUMNUDT1POLBSCN9A | |
| SCHEMBL1548715 | 0.76 | NOTUM (0.43) | MYCKMT2ANOTUMNAPRTKDM4E | |
| SCHEMBL10094229 | 0.75 | NUDT1 (0.45) | KMT2ANOTUMNUDT1L3MBTL1SLC22A12 | |
| SCHEMBL2789857 | 0.74 | NUDT1 (0.55) | KMT2ANOTUMNUDT1L3MBTL1POLB | |
| SCHEMBL24532174 | 0.73 | KDM4C (0.48) | NOTUMNUDT1L3MBTL1KDM4CSLC22A12 | |
| SCHEMBL29681325 | 0.73 | KDM4C (0.48) | NOTUMNUDT1L3MBTL1KDM4CSLC22A12 | |
| SCHEMBL5012014 | 0.72 | NOTUM (0.63) | NOTUMSLC22A12POLB | |
| SCHEMBL2686438 | 0.72 | CTNNB1 (0.44) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL12415902 | 0.72 | HCAR2 (0.48) | POLB | |
| SCHEMBL19859246 | 0.71 | CYP11B2 (0.47) | KMT2ANOTUML3MBTL1SLC22A12POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |