Sugi Predict

Sugi Predict / Compounds / SCHEMBL22719737

SCHEMBL22719737

SCHEMBL22719737

Cc1cc(F)c(Br)cc1Oc1cccc(C(F)(F)F)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TEAD1 P28347 4/20 0.60
▸ NPSR1 Q6W5P4 4/20 0.43
▸ MAPT P10636 3/20 0.43
▸ L3MBTL1 Q9Y468 3/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ THRA P10827 1/20 0.42
▸ THRB P10828 1/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ ATM Q13315 1/20 0.42
▸ EPAS1 Q99814 1/20 0.41
▸ F10 P00742 1/20 0.40
▸ POLB P06746 2/20 0.40
▸ LMNA P02545 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504903 1.00 TEAD1 (0.60) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL22719531 0.83 TEAD1 (0.59) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL22719625 0.80 TEAD1 (0.52) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL4608873 0.80 MAPT (0.55) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL25472566 0.80 TEAD1 (0.55) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL30553089 0.78 TEAD1 (0.49) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL22732096 0.77 TEAD1 (0.58) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL24497305 0.77 TEAD1 (0.53) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL14586640 0.77 NPSR1 (0.50) TEAD1NPSR1MAPTL3MBTL1ALDH1A1
SCHEMBL22731607 0.76 TEAD1 (1.00) TEAD1NPSR1ALDH1A1KDM4EEPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11925651-B2 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-03-12 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-11458149-B1 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-10-04 — — US disclosed
CN-114502540-A TEAD inhibitors and uses thereof 医肯纳肿瘤学公司 2022-05-13 — — CN disclosed
EP-3976192-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2022-04-06 — — EP disclosed
WO-2020243423-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2020-12-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF TEAD2, TEAD3, TEAD4 TEAD1 4/4885NPSR1 4803/4885MAPT 507/4885
US-11925651-B2 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 TEAD1 4/4885NPSR1 4803/4885MAPT 507/4885
US-11458149-B1 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 TEAD1 4/4885NPSR1 4803/4885MAPT 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.