Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748096 | 0.88 | L3MBTL1 (0.55) | TEAD1MAPTL3MBTL1NPSR1TSHR | |
| SCHEMBL25472566 | 0.85 | TEAD1 (0.55) | TEAD1MAPTL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL2748407 | 0.84 | L3MBTL1 (0.60) | MAPTL3MBTL1NPSR1TSHRMAPK1 | |
| SCHEMBL22719531 | 0.82 | TEAD1 (0.59) | TEAD1MAPTL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL4608873 | 0.82 | MAPT (0.55) | TEAD1MAPTL3MBTL1NPSR1TSHR | |
| SCHEMBL22732096 | 0.82 | TEAD1 (0.58) | TEAD1MAPTL3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL2576322 | 0.81 | MAPT (0.52) | TEAD1MAPTL3MBTL1NPSR1TSHR | |
| SCHEMBL29638122 | 0.79 | EGFR (0.53) | MAPTL3MBTL1NPSR1TSHRMAPK1 | |
| SCHEMBL2747848 | 0.79 | EGFR (0.53) | MAPTL3MBTL1NPSR1TSHRMAPK1 | |
| SCHEMBL6153537 | 0.79 | TSHR (0.68) | TEAD1MAPTL3MBTL1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |