Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503109 | 0.84 | HDAC1 (0.47) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2219007 | 0.81 | SMPD1 (0.44) | SMN1; SMN2MAPTLMNAALDH1A1HDAC3 | |
| SCHEMBL22719925 | 0.81 | EGLN2 (0.41) | GAASMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL4304552 | 0.80 | KDM5A (0.40) | SMN1; SMN2MAPTTP53HDAC3HDAC1 | |
| SCHEMBL12444335 | 0.79 | HTT (0.40) | SMN1; SMN2MAPTLMNAALDH1A1HDAC6 | |
| SCHEMBL22719903 | 0.78 | GRIN1 (0.43) | MAPTLMNAALDH1A1EGLN2HPGD | |
| SCHEMBL22738285 | 0.77 | MEN1 (0.40) | MAPTMEN1KMT2AMAPK1HDAC3 | |
| SCHEMBL13577624 | 0.77 | EGLN1 (0.40) | SMN1; SMN2MAPTLMNAALDH1A1HDAC6 | |
| SCHEMBL24065372 | 0.76 | HDAC1 (0.52) | ALDH1A1MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL22738223 | 0.76 | SCN9A (0.41) | MAPTMAPK1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |