Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22720220 | 0.86 | USP30 (0.40) | FPR2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL22724565 | 0.83 | FPR2 (0.43) | FPR2PIK3R1PIK3CANR1H2USP2 | |
| SCHEMBL22720302 | 0.76 | FPR2 (0.40) | FPR2PIK3R1PIK3CANR1H2USP2 | |
| SCHEMBL22999816 | 0.75 | FPR2 (0.43) | FPR2PIK3R1PIK3CANR1H2USP2 | |
| SCHEMBL17188206 | 0.74 | USP30 (0.46) | FPR2PIK3R1PIK3CAMAPTHPGD | |
| SCHEMBL31257362 | 0.74 | USP30 (0.46) | FPR2PIK3R1PIK3CAMAPTHPGD | |
| SCHEMBL30963379 | 0.72 | DDB1 (0.51) | FPR2PIK3R1PIK3CANR1H2USP2 | |
| SCHEMBL2674657 | 0.71 | FPR2 (0.44) | FPR2NR1H2USP2SMN1; SMN2DDB1 | |
| SCHEMBL22720469 | 0.71 | TP53 (0.53) | FPR2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL22720311 | 0.71 | FPR2 (0.42) | FPR2NR1H2USP2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396147-B | Aromatic heterocyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-113396147-A | Aromatic heterocyclic derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-09-14 | — | — | CN | disclosed |
| WO-2020239123-A1 | AROMATIC HETEROCYCLIC DERIVATIVE MODULATOR AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2020-12-03 | — | — | WO | disclosed |