SCHEMBL227218

SCHEMBL227218

O=C(Cl)c1ccnc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 1/20 0.47
NSD2 O96028 1/20 0.45
PTPN1 P18031 1/20 0.45
PTPN11 Q06124 1/20 0.45
LOXL2 Q9Y4K0 1/20 0.44
CYP1A2 P05177 3/20 0.44
PABPC1 P11940 1/20 0.43
EIF4H Q15056 1/20 0.43
HDAC3 O15379 2/20 0.43
HDAC1 Q13547 2/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC2 Q92769 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43
HDAC5 Q9UQL6 2/20 0.43
HDAC4 P56524 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
MAPT P10636 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL229271 0.98 NCF1 (0.46) NCF1NSD2PTPN1PTPN11LOXL2
SCHEMBL1133969 0.87 NSD2 (0.55) NSD2PABPC1EIF4HHDAC6MAPT
Hydrochloric Acid SCHEMBL5450935 0.85 NSD2 (0.54) NSD2PABPC1EIF4HHDAC6MAPT
SCHEMBL23193358 0.84 NCF1 (0.50) NCF1NSD2PTPN1PTPN11LOXL2
SCHEMBL29375172 0.82 KDM4E (0.56) NCF1NSD2CYP1A2MAPTNPC1
SCHEMBL228713 0.82 KDM4E (0.56) NCF1NSD2CYP1A2MAPTNPC1
Hydrochloric Acid SCHEMBL7310592 0.81 KDM4E (0.54) NCF1NSD2CYP1A2MAPTNPC1
SCHEMBL607663 0.81 KDM4E (0.57) NCF1NSD2PTPN1PTPN11LOXL2
SCHEMBL29381262 0.81 KDM4E (0.57) NCF1NSD2PTPN1PTPN11LOXL2
SCHEMBL827639 0.81 MEN1 (0.47) NCF1NSD2PTPN1PTPN11LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993014055-A1 PREPARATION OF 2,5-DICHLOROBENZOPHENONES MAXDEM INCORPORATED (US) 1993-07-22 WO claimed
US-5210313-A Friedel crafts aryloylation of 1,4-dichlorobenzene and Lewis acids MAXDEM INCORPORATED (US) 1993-05-11 US claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
WO-2025027117-A1 CARBOXAMIDE-4-QUINOLINE COMPOUNDS WITH ANTHELMINTIC ACTIVITY INTERVET INTERNATIONAL B.V. (NL) 2025-02-06 WO disclosed
CN-117449806-A Carbonate reservoir hydrocarbon well yield-increasing and blocking-removing liquid and use method thereof 中国石油天然气股份有限公司 2024-01-26 CN disclosed
CN-117384610-A Blocking remover for complex lithology environment and blocking removing method thereof 中国石油天然气股份有限公司 2024-01-12 CN disclosed
CN-117343710-A Quick-reaction blocking removal liquid and filling method thereof 中国石油天然气股份有限公司 2024-01-05 CN disclosed
CN-117345181-A Blocking removing liquid for oil and gas field exploitation and filling method thereof 中国石油天然气股份有限公司 2024-01-05 CN disclosed
CN-117343708-A Hydrate blocking removing liquid and filling method thereof 中国石油天然气股份有限公司 2024-01-05 CN disclosed
CN-113061098-B Amide compound and derivative thereof, preparation method, pharmaceutical composition and application 中国药科大学 2022-08-30 CN disclosed
CN-108430994-B Compounds, compositions and methods for modulating CFTR 蛋白质平衡治疗股份有限公司 2022-04-12 CN disclosed
US-RE32761-E ANALGESICS, ANTIRHEUMATIC AND ANTIINFLAMMATORY AGENT STERLING DRUG INC. (US) 1988-10-04 US disclosed
EP-0266558-A2 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them Roche Diagnostics GmbH (DE) 1988-05-11 EP disclosed
US-4634776-A ANALGESIC, ANTIRHEUMATIC, ANTIINFLAMMATORY STERLING DRUG, INC. (US) 1987-01-06 US disclosed
US-4581354-A ANALGESICS;ANTI-RHEUMATIC AND ANTI-INFLAMMATORY AGENTS STERLING DRUG INC. (US) 1986-04-08 US disclosed
EP-0171037-A2 3-Carbonyl-1-aminoalkyl-1H-indoles useful as analgesics and preparation thereof STERLING WINTHROP INC. (US) 1986-02-12 EP disclosed
US-4087428-A ANTIEMETICS A. H. ROBINS COMPANY, INC. (US) 1978-05-02 US disclosed
US-4073796-A ANTIEMETIC A. H. ROBINS COMPANY, INC. (US) 1978-02-14 US disclosed
US-4039678-A N-(SUBSTITUTED-3-PYRROLIDINYL)-1-NAPHTHALENE CARBOXAMIDES A. H. ROBINS COMPANY, INCORPORATED (US) 1977-08-02 US disclosed
US-4002757-A ANTIEMETIC AGENTS A. H. ROBINS COMPANY, INCORPORATED (US) 1977-01-11 US disclosed