Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | STAT3 | P40763 | 1/20 | 0.72 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22192246 | 0.94 | SMN1; SMN2 (0.81) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL10876762 | 0.88 | SMN1; SMN2 (0.72) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL8361570 | 0.88 | SMN1; SMN2 (0.72) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL4257510 | 0.87 | NR1H4 (0.76) | NPC1KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL22192237 | 0.86 | NPC1 (0.66) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL2839008 | 0.86 | SMN1; SMN2 (0.66) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL2119008 | 0.86 | TRPV1 (0.70) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL8363731 | 0.86 | SMN1; SMN2 (0.69) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL12338996 | 0.86 | TRPV1 (0.70) | NPC1KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL6799157 | 0.86 | RAB9A (1.00) | NPC1KDM4EALDH1A1CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10849841-B2 | Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10849841-B2 | Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH | AR, BPHL, PTGS2 | NPC1 2726/4885KDM4E 4325/4885ALDH1A1 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.