SCHEMBL22723964

SCHEMBL22723964

CCN1CCc2ccc(O[C@H](C)C(F)(F)F)nc2CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DRD3 P35462 20/20 0.51
DRD2 P14416 17/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22723930 0.82 DRD3 (0.63) DRD3DRD2
SCHEMBL22724026 0.77 DRD3 (0.55) DRD3DRD2
SCHEMBL22724053 0.77 DRD3 (0.50) DRD3DRD2
SCHEMBL22724115 0.74 DRD3 (0.55) DRD3DRD2
SCHEMBL22724039 0.74 DRD3 (0.58) DRD3DRD2
SCHEMBL22723932 0.70 CYP3A4 (0.37) DRD2
SCHEMBL22723975 0.70 DRD3 (0.35) DRD3DRD2
SCHEMBL22723986 0.69 DRD3 (0.61) DRD3DRD2
SCHEMBL22723818 0.69 DRD3 (0.59) DRD3DRD2
SCHEMBL23609445 0.65 ADORA2A (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3744721-A1 CONDENSED CYCLIC COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISM Shionogi & Co., Ltd (JP) 2020-12-02 EP disclosed