Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 15/20 | 0.35 |
| ▸ | DRD2 | P14416 | 13/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22723932 | 0.79 | CYP3A4 (0.37) | DRD2CYP3A4TSHRHSD17B10DRD1 | |
| SCHEMBL22723843 | 0.78 | DRD3 (0.46) | DRD3DRD2 | |
| SCHEMBL22961473 | 0.72 | DRD3 (0.51) | DRD3DRD2 | |
| SCHEMBL22723964 | 0.70 | DRD3 (0.51) | DRD3DRD2 | |
| SCHEMBL22723897 | 0.69 | DRD3 (0.44) | DRD3DRD2 | |
| SCHEMBL28890009 | 0.69 | MAPT (0.40) | — | |
| SCHEMBL25060993 | 0.63 | ADRA2A (0.41) | DRD2TSHRHSD17B10DRD1 | |
| SCHEMBL10312982 | 0.63 | NOTUM (0.48) | DRD2DRD1 | |
| SCHEMBL26160914 | 0.63 | PNMT (0.43) | DRD2DRD1 | |
| SCHEMBL21451837 | 0.62 | POLB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495363-B1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | SHIONOGI & CO (JP) | 2023-08-23 | — | — | EP | disclosed |
| EP-3744721-A1 | CONDENSED CYCLIC COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISM | Shionogi & Co., Ltd (JP) | 2020-12-02 | — | — | EP | disclosed |