Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 10/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | CASP1 | P29466 | 7/20 | 0.49 |
| ▸ | CASP7 | P55210 | 7/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | MAT2A | P31153 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22724307 | 0.87 | MAT2A (0.59) | CYP2D6MAT2ACYP2C19CYP2C9 | |
| SCHEMBL22724254 | 0.87 | MAT2A (0.44) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL29837907 | 0.87 | MAT2A (0.59) | CYP2D6MAT2ACYP2C19CYP2C9 | |
| SCHEMBL22724295 | 0.87 | MAT2A (0.44) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL22724344 | 0.86 | MAT2A (0.43) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL22719012 | 0.86 | MAT2A (0.45) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL22724200 | 0.84 | MAT2A (0.46) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL22724480 | 0.84 | MAT2A (0.53) | CYP2D6MAT2ACYP2C19CYP2C9 | |
| SCHEMBL22724264 | 0.84 | MAT2A (0.45) | USP2CYP1A2ALDH1A1CASP1CASP7 | |
| SCHEMBL22724509 | 0.83 | ALDH1A1 (0.44) | USP2CYP1A2ALDH1A1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243376-A1 | HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |