Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vaborbactam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vaborbactam SCHEMBL18967758 | 1.00 | SIGMAR1 (0.45) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| Vaborbactam SCHEMBL620289 | 1.00 | SIGMAR1 (0.45) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| Vaborbactam SCHEMBL622398 | 1.00 | SIGMAR1 (0.45) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL10189424 | 0.93 | POLB (0.48) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL621552 | 0.93 | POLB (0.48) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL10189422 | 0.93 | POLB (0.48) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL21700157 | 0.93 | POLB (0.48) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL10158857 | 0.90 | CYP3A4 (0.45) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL10158855 | 0.90 | CYP3A4 (0.45) | SIGMAR1POLBHSD17B10HPGDALDH1A1 | |
| SCHEMBL22096721 | 0.89 | SIGMAR1 (0.42) | SIGMAR1POLBHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207292-A1 | BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS | TRUSTEES OF TUFTS COLLEGE | 2024-06-27 | — | — | US | disclosed |
| US-20220024949-A1 | CU-AND NI-CATALYZED DECARBOXYLATIVE BORYLATION REACTIONS | THE SCRIPPS RESEARCH INSTITUTE | 2022-01-27 | — | — | US | disclosed |
| WO-2020243008-A1 | SENSORS AND METHODS FOR RAPID MICROBIAL DETECTION | BAMBU VAULT LLC (US) | 2020-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240207292-A1 | BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS | BCL6B, BCL6, BTD | SIGMAR1 3790/4885POLB 1288/4885HSD17B10 2957/4885 |
| US-20220024949-A1 | CU-AND NI-CATALYZED DECARBOXYLATIVE BORYLATION REACTIONS | PCSK9, PCSK7, PCSK6 | SIGMAR1 4472/4885POLB 1446/4885HSD17B10 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.