Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158855 | 1.00 | CYP3A4 (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| SCHEMBL10158925 | 0.93 | POLB (0.47) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| SCHEMBL10158979 | 0.93 | POLB (0.47) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| Vaborbactam SCHEMBL622398 | 0.90 | SIGMAR1 (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| Vaborbactam SCHEMBL22726486 | 0.90 | SIGMAR1 (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| Vaborbactam SCHEMBL18967758 | 0.90 | SIGMAR1 (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| Vaborbactam SCHEMBL620289 | 0.90 | SIGMAR1 (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| SCHEMBL18251781 | 0.90 | POLB (0.46) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| SCHEMBL21700140 | 0.90 | POLB (0.46) | CYP3A4POLBALDH1A1HSD17B10TSHR | |
| SCHEMBL10189589 | 0.87 | POLB (0.45) | CYP3A4POLBALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230277571-A1 | THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | MELINTA SUBSIDIARY CORP. | 2023-09-07 | — | — | US | disclosed |
| US-11684629-B2 | Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives | MELINTA SUBSIDIARY CORP. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20180214465-A1 | THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | MELINTA SUBSIDIARY CORP. | 2018-08-02 | — | — | US | disclosed |
| US-20180207183-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | MELINTA SUBSIDIARY CORP. | 2018-07-26 | — | — | US | disclosed |
| US-10004758-B2 | Cyclic boronic acid ester derivatives and methods of making the same | REMPEX PHARMACEUTICALS, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20180071325-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND METHODS OF MAKING THE SAME | MELINTA SUBSIDIARY CORP. | 2018-03-15 | — | — | US | disclosed |
| US-9694025-B2 | Cyclic boronic acid ester derivatives and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160220591-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF | MELINTA SUBSIDIARY CORP. | 2016-08-04 | — | — | US | disclosed |
| US-9296763-B2 | Cyclic boronic acid ester derivatives and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-8680136-B2 | Cyclic boronic acid ester derivatives and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120040932-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207183-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | BCL6B, SLC10A2, ABCB11 | CYP3A4 687/4885POLB 1208/4885ALDH1A1 3286/4885 |
| US-20180214465-A1 | THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | BCL6B, BCL6, SLC10A2 | CYP3A4 1934/4885POLB 1037/4885ALDH1A1 3278/4885 |
| US-20160220591-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF | BCL6B, BCL6, BCL9 | CYP3A4 2420/4885POLB 1247/4885ALDH1A1 2889/4885 |
| US-20180071325-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND METHODS OF MAKING THE SAME | BCL6B, BCL6, BCR | CYP3A4 892/4885POLB 841/4885ALDH1A1 2978/4885 |
| US-20120040932-A1 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF | BCL6B, BCL6, BCL9 | CYP3A4 2455/4885POLB 1052/4885ALDH1A1 2354/4885 |
| US-11684629-B2 | Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives | BCL6B, BCL6, SLC10A2 | CYP3A4 1934/4885POLB 1037/4885ALDH1A1 3278/4885 |
| US-10004758-B2 | Cyclic boronic acid ester derivatives and methods of making the same | BCL6B, BCL6, BCR | CYP3A4 892/4885POLB 841/4885ALDH1A1 2978/4885 |
| US-20230277571-A1 | THERAPEUTIC USES OF PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLIC BORONIC ACID ESTER DERIVATIVES | BCL6B, BCL6, SLC10A2 | CYP3A4 1934/4885POLB 1037/4885ALDH1A1 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.