Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 8/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | LITAF | Q99732 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25240038 | 1.00 | HTR6 (0.43) | HTR6BCHEJAK1EGFRSRC | |
| SCHEMBL29460624 | 1.00 | HTR6 (0.43) | HTR6BCHEJAK1EGFRSRC | |
| SCHEMBL25284995 | 1.00 | HTR6 (0.43) | HTR6BCHEJAK1EGFRSRC | |
| SCHEMBL2284399 | 0.96 | JAK1 (0.47) | HTR6BCHEJAK1EGFRSRC | |
| SCHEMBL2224575 | 0.95 | HTR6 (0.46) | HTR6BCHEJAK1JAK2 | |
| SCHEMBL2276584 | 0.90 | HTR6 (0.47) | HTR6BCHE | |
| SCHEMBL13823531 | 0.90 | JAK1 (0.43) | HTR6JAK1JAK2 | |
| SCHEMBL25693615 | 0.89 | HTR6 (0.45) | HTR6BCHEEGFRSRCPIK3CA | |
| SCHEMBL25285310 | 0.88 | JAK1 (0.41) | HTR6BCHEJAK1EGFRSRC | |
| SCHEMBL27433382 | 0.88 | JAK1 (0.41) | HTR6BCHEJAK1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |