Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16186449 | 0.85 | ALDH1A1 (0.61) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL457828 | 0.85 | MAOB (0.54) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL2628178 | 0.84 | MAOB (0.59) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL29530517 | 0.83 | MAOB (0.48) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL9486297 | 0.83 | ALDH1A1 (0.70) | ALDH1A1MAOBSMN1; SMN2MEN1MAPT | |
| SCHEMBL3842164 | 0.83 | MAOB (0.52) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL20566087 | 0.81 | MAOB (0.47) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL24364239 | 0.81 | MAOB (0.44) | ALDH1A1MAOBMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL3839157 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAOBSMN1; SMN2MEN1MAPT | |
| SCHEMBL3838974 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAOBSMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377474-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | BRDT, BRD4, BRD3 | ALDH1A1 1617/4885MAOB 289/4885MAPK1 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.