Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717565 | 0.90 | DHODH (0.42) | HTTNPC1THRBRAB9AKMT2A | |
| SCHEMBL29575407 | 0.90 | DHODH (0.42) | HTTNPC1THRBRAB9AKMT2A | |
| SCHEMBL22717528 | 0.89 | VDR (0.43) | HTTNPC1THRBRAB9AMEN1 | |
| SCHEMBL22732241 | 0.84 | PARP1 (0.46) | CDC7PARP1MAPK8MAPK10HTT | |
| SCHEMBL22732273 | 0.83 | NNMT (0.52) | CDC7PARP1MAPK8MAPK10HTT | |
| SCHEMBL22732085 | 0.82 | POLQ (0.51) | CDC7PARP1MAPK8MAPK10HTT | |
| SCHEMBL22732240 | 0.80 | CCNT1 (0.47) | CDC7PARP1MAPK8MAPK10HTT | |
| SCHEMBL22732063 | 0.76 | CDC7 (0.43) | CDC7PARP1MAPK8HTTLMNA | |
| SCHEMBL22717582 | 0.75 | VDR (0.46) | HTTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL29575360 | 0.75 | VDR (0.46) | HTTMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |