Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30402704 | 0.90 | DGAT1 (0.33) | F2RL1DGAT1 | |
| SCHEMBL19745461 | 0.90 | DGAT1 (0.33) | F2RL1DGAT1 | |
| SCHEMBL24211029 | 0.83 | ADRA2A (0.44) | F2RL1NPC1DGAT1ADRA2A | |
| SCHEMBL30304731 | 0.82 | DGAT1 (0.35) | F2RL1NPC1DGAT1ADRA2A | |
| SCHEMBL29340464 | 0.82 | DGAT1 (0.37) | F2RL1DGAT1ADRA2A | |
| SCHEMBL31357963 | 0.82 | DGAT1 (0.33) | F2RL1DGAT1ADRA2A | |
| SCHEMBL31009894 | 0.82 | DGAT1 (0.37) | F2RL1DGAT1ADRA2A | |
| SCHEMBL14738462 | 0.82 | DGAT1 (0.37) | F2RL1NPC1DGAT1RAB9AADRA2A | |
| SCHEMBL19745660 | 0.80 | — | — | |
| SCHEMBL32687927 | 0.80 | DHODH (0.36) | F2RL1NPC1DGAT1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |