Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23710207 | 1.00 | HRH3 (0.34) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL22732893 | 0.85 | HTR4 (0.43) | HRH3HTR4 | |
| SCHEMBL24170954 | 0.83 | HTR4 (0.36) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24626883 | 0.83 | HTR4 (0.33) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24626880 | 0.83 | HTR4 (0.36) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24170952 | 0.83 | HTR4 (0.33) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24170835 | 0.83 | HTR4 (0.33) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL23487053 | 0.81 | HRH3 (0.39) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL3513759 | 0.78 | HTR4 (0.39) | HTR4 | |
| SCHEMBL22732596 | 0.77 | HRH3 (0.35) | HRH3PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078398-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2023-05-11 | — | — | WO | disclosed |
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020238785-A1 | METHYL- AND TRIFLUOROMETHYL-CONTAINING DISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITOR | 正大天晴药业集团股份有限公司 | 2020-12-03 | — | — | WO | disclosed |