Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22732597 | 0.85 | HRH3 (0.34) | HTR4HRH3 | |
| SCHEMBL23710207 | 0.85 | HRH3 (0.34) | HTR4HRH3 | |
| SCHEMBL22732724 | 0.83 | HTR4 (0.45) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL24171111 | 0.83 | HTR4 (0.43) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL24626968 | 0.83 | HTR4 (0.43) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL24170836 | 0.83 | HTR4 (0.43) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL23710030 | 0.81 | HRH3 (0.47) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL24627203 | 0.81 | HTR4 (0.42) | HTR4HRH3EPHA2KDR | |
| SCHEMBL22732727 | 0.78 | HRH3 (0.42) | HTR4HRH3EPHA2KDRKCNH2 | |
| SCHEMBL22732611 | 0.78 | HRH3 (0.42) | HTR4HRH3EPHA2KDRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858832-A1 | TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020238785-A1 | METHYL- AND TRIFLUOROMETHYL-CONTAINING DISUBSTITUTED SULFONAMIDE SELECTIVE BCL-2 INHIBITOR | 正大天晴药业集团股份有限公司 | 2020-12-03 | — | — | WO | disclosed |