Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22732754 | 0.86 | KMT2A (0.43) | MAPTLMNAACACBTP53KMT2A | |
| SCHEMBL22745802 | 0.80 | RXRA (0.47) | MAPTACACBTP53KMT2AMCL1 | |
| SCHEMBL22712504 | 0.75 | KMT2A (0.56) | MAPTLMNAACACBTP53KMT2A | |
| SCHEMBL8270868 | 0.74 | PARP10 (0.38) | MAPTHPGDACACBTP53KMT2A | |
| SCHEMBL22732764 | 0.73 | KDM4E (0.40) | MAPTACACBTP53KMT2AKDM4E | |
| SCHEMBL22712537 | 0.73 | KMT2A (0.45) | MAPTHPGDTSHRPOLBLMNA | |
| SCHEMBL23605226 | 0.71 | RXRA (0.40) | MAPTHPGDPOLBTP53KMT2A | |
| SCHEMBL22712499 | 0.71 | ALDH1A1 (0.67) | MAPTHPGDHTTLMNAKMT2A | |
| SCHEMBL1321790 | 0.71 | NPSR1 (0.37) | MAPTHPGDHTTPOLBL3MBTL1 | |
| SCHEMBL26228637 | 0.70 | KMT2A (0.44) | MAPTPOLBLMNAACACBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243155-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | GENENTECH, INC. (US) | 2020-12-03 | — | — | WO | disclosed |