Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 5/20 | 0.58 |
| ▸ | TYK2 | P29597 | 4/20 | 0.58 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30501963 | 1.00 | JAK1 (0.58) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL30501968 | 0.88 | JAK1 (0.57) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576307 | 0.88 | JAK1 (0.57) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL25375414 | 0.80 | JAK1 (0.57) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL31097633 | 0.80 | JAK1 (0.57) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576507 | 0.79 | JAK1 (0.36) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22735004 | 0.79 | JAK1 (0.45) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL30502008 | 0.79 | JAK1 (0.45) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22467652 | 0.77 | GPR119 (0.49) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576086 | 0.77 | JAK2 (0.49) | JAK1JAK2TYK2JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728253-B1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2024-03-27 | — | — | EP | disclosed |
| US-11912703-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912703-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912703-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-27 | — | — | US | disclosed |
| CN-111699185-B | 6-azaindole compounds | 百时美施贵宝公司 | 2023-06-27 | — | — | CN | disclosed |
| US-20220348576-A1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-03 | — | — | US | disclosed |
| US-11427580-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-30 | — | — | US | disclosed |
| US-11427580-B2 | 6-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-30 | — | — | US | disclosed |
| US-20200385382-A1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-12-10 | — | — | US | disclosed |
| US-20200385382-A1 | 6-AZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-12-10 | — | — | US | disclosed |
| CN-111699185-A | 6-azaindole compounds | 百时美施贵宝公司 | 2020-09-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912703-B2 | 6-azaindole compounds | TLR7, TLR9, TLR5 | JAK1 302/4885JAK2 211/4885TYK2 670/4885 |
| US-20220348576-A1 | 6-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | JAK1 302/4885JAK2 211/4885TYK2 670/4885 |
| US-20200385382-A1 | 6-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | JAK1 302/4885JAK2 211/4885TYK2 670/4885 |
| US-11427580-B2 | 6-azaindole compounds | TLR7, TLR9, TLR5 | JAK1 302/4885JAK2 211/4885TYK2 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.