Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735004 | 1.00 | JAK1 (0.45) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576483 | 0.89 | JAK2 (0.44) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL30502007 | 0.89 | JAK2 (0.44) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576137 | 0.80 | KDM4E (0.47) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22576477 | 0.80 | GPR119 (0.41) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL30501978 | 0.80 | GPR119 (0.41) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL30501963 | 0.79 | JAK1 (0.58) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL22734993 | 0.79 | JAK1 (0.58) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL28480172 | 0.77 | KDM4E (0.51) | JAK1JAK2TYK2JAK3KDM4E | |
| SCHEMBL20135077 | 0.73 | MAPT (0.52) | JAK1JAK2TYK2JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111699185-B | 6-azaindole compounds | 百时美施贵宝公司 | 2023-06-27 | — | — | CN | disclosed |