Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | FOS | P01100 | 2/20 | 0.34 |
| ▸ | JUN | P05412 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239906 | 0.83 | CRHBP (0.38) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL4849339 | 0.82 | CRHBP (0.38) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL16635020 | 0.81 | ALDH1A1 (0.41) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL20029632 | 0.78 | MEN1 (0.35) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL29139295 | 0.77 | CRHBP (0.35) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL29192762 | 0.77 | KMT2A (0.36) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL23009907 | 0.76 | MEN1 (0.42) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL4852951 | 0.75 | CRHBP (0.44) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL8694142 | 0.74 | ALDH1A1 (0.40) | CRHBPCRHR2HPGDALDH1A1MEN1 | |
| SCHEMBL23009971 | 0.74 | MEN1 (0.39) | CRHBPCRHR2HPGDALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020242935-A1 | METHODS OF TREATMENT FOR CYSTIC FIBROSIS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-03 | — | — | WO | disclosed |