Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.33 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480529 | 1.00 | BTK (0.42) | BTKBRD4ROCK2ROCK1JAK1 | |
| SCHEMBL22736139 | 0.94 | BTK (0.41) | BTKBRD4ROCK2ROCK1JAK1 | |
| SCHEMBL29480545 | 0.93 | BTK (0.39) | BTKBRD4ROCK2JAK1JAK2 | |
| SCHEMBL22735988 | 0.87 | BTK (0.42) | BTKBRD4JAK1JAK2 | |
| SCHEMBL29480557 | 0.87 | BTK (0.42) | BTKBRD4JAK1JAK2 | |
| SCHEMBL22736128 | 0.85 | BTK (0.41) | BTKBRD4JAK1JAK2 | |
| SCHEMBL29480508 | 0.85 | BTK (0.41) | BTKBRD4JAK1JAK2CDK9 | |
| SCHEMBL29567233 | 0.85 | BTK (0.41) | BTKBRD4JAK1JAK2 | |
| SCHEMBL22736207 | 0.83 | JAK1 (0.37) | ROCK2ROCK1JAK1JAK2TYK2 | |
| SCHEMBL29480525 | 0.82 | BTK (0.41) | BTKBRD4JAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |