Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 11/20 | 0.37 |
| ▸ | JAK2 | O60674 | 11/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480557 | 1.00 | BTK (0.42) | BTKJAK1JAK2BRD4 | |
| SCHEMBL29567233 | 0.92 | BTK (0.41) | BTKJAK1JAK2BRD4 | |
| SCHEMBL22736128 | 0.92 | BTK (0.41) | BTKJAK1JAK2BRD4 | |
| SCHEMBL22735884 | 0.87 | BTK (0.42) | BTKJAK1JAK2BRD4 | |
| SCHEMBL29480529 | 0.87 | BTK (0.42) | BTKJAK1JAK2BRD4 | |
| SCHEMBL22736139 | 0.85 | BTK (0.41) | BTKJAK1JAK2BRD4 | |
| SCHEMBL29480508 | 0.83 | BTK (0.41) | BTKJAK1JAK2BRD4 | |
| SCHEMBL29480545 | 0.83 | BTK (0.39) | BTKJAK1JAK2BRD4 | |
| SCHEMBL22736054 | 0.76 | BTK (0.42) | BTKJAK1JAK2BRD4 | |
| SCHEMBL22736466 | 0.76 | BRD4 (0.42) | BTKJAK1JAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |