Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480529 | 0.85 | BTK (0.42) | BTKBRD4CDK9JAK1JAK2 | |
| SCHEMBL22735884 | 0.85 | BTK (0.42) | BTKBRD4CDK9JAK1JAK2 | |
| SCHEMBL22736139 | 0.83 | BTK (0.41) | BTKSPRBRD4JAK1JAK2 | |
| SCHEMBL22735988 | 0.83 | BTK (0.42) | BTKBRD4JAK1JAK2 | |
| SCHEMBL29480557 | 0.83 | BTK (0.42) | BTKBRD4JAK1JAK2 | |
| SCHEMBL22736128 | 0.82 | BTK (0.41) | BTKRETBRD4JAK1JAK2 | |
| SCHEMBL29567233 | 0.82 | BTK (0.41) | BTKRETBRD4JAK1JAK2 | |
| SCHEMBL29480545 | 0.81 | BTK (0.39) | BTKBRD4CDK9JAK1JAK2 | |
| SCHEMBL22736466 | 0.78 | BRD4 (0.42) | BTKBRD4JAK1JAK2 | |
| SCHEMBL22735987 | 0.77 | BTK (0.37) | BTKBRD4CASP3CDK9CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |