Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 6/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480484 | 0.94 | GRM4 (0.35) | MELKGRM4RIPK2AURKAAURKB | |
| SCHEMBL22736238 | 0.94 | GRM4 (0.35) | MELKGRM4RIPK2AURKAAURKB | |
| SCHEMBL22736196 | 0.89 | KDM4A (0.38) | MELKGRM4PDGFRAFLT3HASPIN | |
| SCHEMBL29480606 | 0.89 | KDM4A (0.38) | MELKGRM4PDGFRAFLT3HASPIN | |
| SCHEMBL29480547 | 0.86 | JAK2 (0.39) | CDK9 | |
| SCHEMBL29480486 | 0.81 | JAK2 (0.34) | GRM4 | |
| SCHEMBL22735736 | 0.81 | JAK2 (0.34) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480633 | 0.81 | JAK2 (0.34) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736484 | 0.80 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29480552 | 0.80 | GRM4 (0.35) | GRM4AURKAAURKBINCENPTPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |