Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480633 | 1.00 | JAK2 (0.34) | JAK2GRM4JAK1AURKAAURKB | |
| SCHEMBL22736154 | 0.89 | GRM4 (0.41) | JAK2GRM4JAK1AURKAAURKB | |
| SCHEMBL29480544 | 0.87 | JAK2 (0.39) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL22736238 | 0.86 | GRM4 (0.35) | JAK2GRM4AURKAAURKBINCENP | |
| SCHEMBL29480484 | 0.86 | GRM4 (0.35) | JAK2GRM4AURKAAURKBINCENP | |
| SCHEMBL29480594 | 0.85 | GRM4 (0.35) | JAK2GRM4JAK1AURKAAURKB | |
| SCHEMBL22736083 | 0.85 | GRM4 (0.35) | JAK2GRM4JAK1AURKAAURKB | |
| SCHEMBL29480524 | 0.81 | JAK2 (0.33) | JAK2GRM4JAK1JAK3TYK2 | |
| SCHEMBL22735896 | 0.81 | MELK (0.36) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL22736297 | 0.80 | ALDH1A1 (0.38) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |