Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734040 | 0.78 | GAA (0.42) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL12443590 | 0.76 | HPGD (0.60) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL13424113 | 0.75 | HPGD (0.55) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL23534886 | 0.74 | KDM4E (0.41) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL929672 | 0.74 | PDCD1 (0.43) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL16281097 | 0.74 | KDM4E (0.45) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL16281077 | 0.73 | KDM4E (0.47) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| SCHEMBL7183123 | 0.73 | NPC1 (0.44) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16741194 | 0.73 | PDCD1 (0.43) | KDM4ENPC1RAB9ARXFP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2753179 | 0.73 | PDCD1 (0.43) | KDM4ENPC1RAB9ARXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200375987-A1 | METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375987-A1 | METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF | SLC11A2, MMP12, LCT | KDM4E 1897/4885NPC1 674/4885RAB9A 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.