Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CBLB | Q13191 | 6/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945460 | 0.70 | MAP3K5 (0.55) | CBLB | |
| SCHEMBL23720725 | 0.68 | CBLB (0.43) | HRH4CBLBNTRK1MAP4K1LCK | |
| SCHEMBL23721179 | 0.67 | CBLB (0.35) | CBLBPDGFRB | |
| SCHEMBL21469736 | 0.60 | MAP3K5 (0.48) | — | |
| Hydrochloric Acid SCHEMBL5227057 | 0.60 | HRH4 (0.46) | HRH4USP30 | |
| SCHEMBL27644149 | 0.60 | HRH4 (0.44) | HRH4USP30 | |
| SCHEMBL2563476 | 0.59 | USP30 (0.43) | HRH4USP30ACACB | |
| SCHEMBL29951919 | 0.57 | USP30 (0.48) | USP30ACACB | |
| SCHEMBL19458953 | 0.57 | HRH4 (0.68) | HRH4ACACB | |
| SCHEMBL846850 | 0.57 | HRH4 (0.68) | HRH4ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-B1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-12-02 | — | — | EP | disclosed |