Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 5/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946466 | 0.72 | MAP3K5 (0.51) | CBLBMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL945258 | 0.72 | MAP3K5 (0.61) | CBLBMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL943672 | 0.71 | MAP3K5 (0.51) | MAP3K5 | |
| SCHEMBL23720730 | 0.68 | MAP3K5 (0.36) | CBLBMAP3K5 | |
| SCHEMBL22739188 | 0.67 | HRH4 (0.38) | CBLBPDGFRB | |
| SCHEMBL23721070 | 0.67 | MAP3K5 (0.35) | MAP3K5 | |
| SCHEMBL945284 | 0.66 | CNR1 (0.49) | CBLBMAP4K4CSNK1G2CLK4MKNK2 | |
| SCHEMBL22739206 | 0.66 | MAP3K5 (0.48) | MAP3K5 | |
| SCHEMBL943940 | 0.65 | MAP3K5 (0.45) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL23721197 | 0.64 | CBLB (0.31) | CBLBMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858824-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |