SCHEMBL2274155

SCHEMBL2274155

CCCCc1c([SiH3])ccc(N(C)C)c1CCCC

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
HTT P42858 1/20 0.32
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ESR1 P03372 1/20 0.31
NCEH1 Q6PIU2 1/20 0.30
SKP2 Q13309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8473423 0.79 TYR (0.40) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL2272735 0.76
SCHEMBL3886767 0.75 TYR (0.41) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL2271479 0.73 TYMP (0.38) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL27544494 0.73 TYR (0.49) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL2274425 0.70 NPC1 (0.32) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL2270081 0.69 CYP3A4 (0.33) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL15301727 0.68 TYMP (0.37) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL15302186 0.68 F2RL1 (0.33) NPC1HPGDMAPK1HTTRAB9A
SCHEMBL7358756 0.67 NCEH1 (0.51) NPC1HPGDMAPK1HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed