Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31167506 | 0.84 | HDAC8 (0.57) | HDAC8HDAC4HDAC7HDAC5HDAC6 | |
| SCHEMBL22743540 | 0.82 | HDAC8 (0.55) | HDAC8HDAC4HDAC7HDAC5HDAC6 | |
| SCHEMBL2260946 | 0.82 | PTAFR (0.41) | HDAC8HDAC4HDAC7HDAC5HDAC6 | |
| SCHEMBL2258835 | 0.78 | HDAC8 (0.57) | HDAC8HDAC4HDAC6HPGDHDAC3 | |
| SCHEMBL86872 | 0.78 | DNMT1 (0.53) | HDAC8HDAC4DNMT1RAD52UHRF1 | |
| Bromide SCHEMBL2260972 | 0.77 | HDAC8 (0.56) | HDAC8HDAC4HDAC6HPGDHDAC3 | |
| Bromide SCHEMBL81705 | 0.74 | LGMN (0.46) | HPGD | |
| SCHEMBL12985464 | 0.72 | HDAC8 (0.42) | HDAC8HDAC4HDAC7HDAC5HDAC6 | |
| SCHEMBL87137 | 0.70 | HDAC8 (0.40) | HDAC8HDAC4HDAC7HDAC5HDAC6 | |
| SCHEMBL80988 | 0.69 | GAA (0.47) | HDAC8HDAC6PTGS2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |