Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29472135 | 0.78 | METAP2 (0.43) | MAP4K4NPC1RAB9APIK3CGPIK3CD | |
| SCHEMBL22744476 | 0.76 | MAP4K4 (0.67) | MAP4K4MINK1TNIK | |
| SCHEMBL15537120 | 0.75 | KDM4E (0.49) | PIK3CGPIK3CDPIK3CAIDO1ALDH1A1 | |
| SCHEMBL22744270 | 0.74 | MAP4K4 (0.45) | MAP4K4GRM5ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22744438 | 0.73 | MAP4K4 (0.47) | MAP4K4MINK1TNIK | |
| SCHEMBL8274296 | 0.72 | ATM (0.48) | GRM5IDO1ABCG2 | |
| SCHEMBL22744605 | 0.71 | MAP4K4 (0.45) | MAP4K4ALDH1A1CYP1A2CYP3A4CLK4 | |
| SCHEMBL4119442 | 0.71 | NPC1 (0.56) | MAP4K4NPC1RAB9APIK3CDPIK3CA | |
| SCHEMBL4107230 | 0.71 | KMO (0.47) | MAP4K4NPC1RAB9APIK3CGPIK3CD | |
| SCHEMBL737948 | 0.71 | EGFR (0.55) | PIK3CDPIK3CAALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239999-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-03 | — | — | WO | disclosed |