Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24478773 | 0.89 | MAP4K4 (0.44) | PIK3CAHDAC1CNR2ALDH1A1MAPT | |
| SCHEMBL28445732 | 0.83 | PIK3CA (0.74) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL28726504 | 0.80 | CNR2 (0.36) | PIK3CAHDAC1CNR2ALDH1A1MAPT | |
| SCHEMBL27046655 | 0.79 | EGFR (0.40) | PIK3CAHDAC1CNR2ALDH1A1MAPT | |
| SCHEMBL29544044 | 0.79 | EGFR (0.40) | PIK3CAHDAC1CNR2ALDH1A1MAPT | |
| SCHEMBL28460296 | 0.78 | ALDH1A1 (0.48) | PIK3CAHDAC1ALDH1A1MAPT | |
| SCHEMBL22744980 | 0.78 | PIK3CA (0.53) | PIK3CAHDAC1PIK3R1 | |
| SCHEMBL22745224 | 0.75 | PIK3CA (0.46) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL28449619 | 0.72 | PIK3CA (0.76) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22732557 | 0.71 | MAP4K4 (0.39) | PIK3CAHDAC1PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239951-A1 | AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-12-03 | — | — | WO | disclosed |