SCHEMBL227471

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL228610	0.85	CALM1 (0.49)	ESR2ESR1CYP19A1CALM1ABL1
	SCHEMBL4736569	0.83	ESR1 (0.82)	ESR2ESR1CYP19A1CALM1NFKB1
	SCHEMBL228557	0.82	ABCB1 (0.60)	MAPTFFAR1ABCB1MAOBFFAR4
	SCHEMBL227115	0.81	ESR1 (0.73)	ESR2ESR1CYP19A1CALM1RAB9A
	SCHEMBL3414787	0.80	CALM1 (0.84)	ESR2ESR1CYP19A1CALM1NPC1
	SCHEMBL225166	0.79	ESR1 (0.58)	ESR2ESR1CYP19A1CALM1NPC1
	SCHEMBL1847390	0.78	ESR1 (0.69)	ESR2ESR1CYP19A1CALM1NPC1
	SCHEMBL29492427	0.78	ESR1 (0.69)	ESR2ESR1CYP19A1CALM1NPC1
	SCHEMBL228848	0.77	CD74 (0.50)	ESR2ESR1CYP19A1FFAR1ABL1
	SCHEMBL5137000	0.77	ESR2 (0.47)	ESR2ESR1CYP19A1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.