Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747858 | 0.85 | FOLH1 (0.40) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747865 | 0.84 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747868 | 0.82 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760070 | 0.82 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760364 | 0.80 | FOLH1 (0.37) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760117 | 0.79 | FOLH1 (0.36) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22747829 | 0.77 | FOLH1 (0.35) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760085 | 0.77 | EDNRA (0.37) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22748249 | 0.77 | FOLH1 (0.39) | FOLH1LMNATSHRALDH1A1GAA | |
| SCHEMBL22760471 | 0.77 | FOLH1 (0.44) | FOLH1LMNAALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |